5-HTP is primarily used to support mood through its ability to boost serotonin levels. It has been compared to various tricyclic antidepressants, and has been found to be as effective with fewer side effects and quicker effectiveness. Since serotonin and melatonin are involved in regulating the sleep/wake cycle, 5-HTP also enhances sleep quality. Additionally, research supports a role for 5-HTP in reducing migraines and the symptoms of fibromyalgia. Studies in Spain and Italy found that 5-HTP was comparable to the drug methysergide in alleviating the symptoms of migraines (over 70% in both groups) while eliciting considerably fewer side effects. Fibromyalgia patients have been found to have low serotonin levels and have shown symptomatic improvement with the use of tricyclic and SSRI antidepressants. Several clinical trials have confirmed significant improvements in symptoms, including pain, morning stiffness, nervousness, and fatigue.
AOR’s 5-HTP is derived from the seed of the small shrub tree Griffonia simplicifolia and then processed in France. This source of 5-HTP is devoid of any “peak x” contaminants. AOR also offers 5-HTP Extra Strength, which is twice the dose of AOR’s regular 5-HTP, to meet varying individual needs.
For healthy mood balance, take one to two capsules three times daily with food; for relief of symptoms of fibromyalgia, take two capsules three to four times daily with food. To minimize gastrointestinal side effect risk, start at 50 to 100 mg two to three times daily and slowly increase to an effective dose over two weeks. Use for a minimum of one week to see beneficial effects for mood balance and two weeks for the alleviation of fibromyalgia symptoms. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year.
Consult a health care practitioner prior to use if taking carbidopa or drugs/supplements with serotonergic activity, including, but not limited to, L-tryptophan, SAMe, St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea medication or anti-migraine medication. Some people may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting and abdominal pain. May cause drowsiness; exercise caution if driving or operating heavy machinery or engaging in activities requiring mental alertness. Discontinue use and consult a health care practitioner if you experience skin changes, weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain.
Do not use if you have scleroderma, if you are pregnant, breastfeeding, or trying to conceive. Not to be used by individuals under the age of 18 or those with a medical condition. This product contains corn, do not use if you have an allergy. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year.